Afaik, Zooble's the only canonically trans character. I mean, the nightmare segment of ep8 was VERY obviously about their severe dysphoria, as well as their couch therapy gag with Caine. Hell, their whole body design was Caine's pretty lame attempt at alleviating their dysphoria by giving them dysmorphia instead.

Tbh, I was very pleasantly surprised by how seriously they took depicting actual computer science. There is a world of difference between Kinger with the bucket on his head missing a keystroke and this shit.