It's gonna affect anyone who's just barely running out of vram. If You're not straddling the limit you won't notice it.

I'm using a 6650XT and have seen sizeable boosts in scenarios where previously it would lag like crazy. I'll be honest I didn't expect to see much of a change at all. But given this is just one step above the 6500 id suggest anyone on a 8gb give it a shot when it's available for your distro. I'm wondering what it will be like with something like Doom Eternal which normally wants 10 or more gig for best performance.