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Vyvanse makes the line go up (piefed.cdn.blahaj.zone)
submitted 6 months ago by to c/adhd@lemmy.dbzer0.com
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A skeleton squats a barbell behind text that reads “my body is a machine that turns lisdexamphetamine into shareholder value “
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[–] 1 point 6 months ago (3 children)

Yall taking the og right? The generic is absolutely fucking garbage and doesn't work for shit.

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  • [–] 3 points 6 months ago (2 children)

    I don't think it's quite like that, I think it's more that an important part of these drugs is the release mechanism - and any two given brands will work differently for a given person.

    I take long release methylphenidate (Ritalin/Concerta being the most known brands). I started with Medikinet because that's the main recommendation from my healthcare provider. It turned out it releases most of the dosage in the short term and at 40mg doses I constantly felt like I was at an airport with my boarding gate closing in seconds.

    Moved to Meflynate, which is also methylphenidate hydrochloride, and now I'm a happy bunny.

    My point being - it's not that generics are bad necessarily, it's more like, only a certain brand(s) will work for you. Whether for you that's the more expensive or cheaper one, it's a bit of a lottery really.

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  • [–] 3 points 6 months ago

    Lisdexafetamine is somewhat unique because the slow release mechanism is more or less inherent to the actual drug itself. That is, the fact that lisdexamfetamine is a prodrug that needs to be processed into dextroamphetamine (the actual stimulant) is the slow release mechanism itself.

    Methylphenidate is different because the chemical itself is the stimulant, so pharmaceutical companies need to come up with ways to physically release it slowly, e.g. via mini capsules that dissolve slowly.

    Unfortunately every brand and formulation kind of does their own thing in order to differentiate themselves from generics.

    IIRC Concerta was the most "advanced" in the sense that they formulated a special double release system where each dose also dissolved slowly. Ritalin LA is much jankier because it basically just released a second or third dose all once later on.

    You can search "name of drug" + pharmacokinetics to get more graphs, which in combination with keeping a mood diary can help in nailing down hat works for you.

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  • [–] 1 point 6 months ago

    Yeah that's the thing it's all about the time release. Correct me if I'm wrong but vyvance big thing is that it.... fuck I forgot it the most of it but it slowly release through the liver because of a extra molecule on the drug. This makes it that your body only sucks it up as needed. When blood levels drop. So allegedly its damn hard to overdose on vyvance. The larger doses are only for how long of a day last for. 40mg 8hrs 60mg 10hrs etc.

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