Are you asking to change the definition of a car trip to the ~500,000 miles it takes to get to the moon and back?

In that case, rate of fatality is around 1 in 200 "driving to the moon and back" trips. 0.5% chance. So taking the rocketship is still significantly more dangerous.

More realistically, 500,000 miles is roughly a lifetime of driving. So these astronauts are being exposed in a single trip to a fatality risk equivalent of 2+ lifetimes of driving.