I had a fairly high end drawing pad no matter what I did, I could not get it to work properly on Linux. I needed up purchasing another and it worked perfectly fine with very little setup required. My work used to require Adobe After Effects and Adobe Premiere, but not long ago, maybe a year, they changed the workflow and I am no longer on the team that has to use those tools.

Otherwise, I've had very little issues, even with gaming. I think I've ran into 3, maybe 4, titles that wouldn't work on Linux, but they were kind of niche games. Most modern titles with even a moderately large audiences work just fine.