The main problem is when following instructions for command line tools. They might figure out how to use dnf instead of apt, but the extra layers required for ostree are not very friendly. There are a ton of potential frustrations in this area, especially with GPU stuff or hobbyist hardware like Arduino where kernel stuff is needed in userland. At least as of nearly 3 years ago, the documentation in this area sucks. I was on Silverblue for a few years and managed to get through the frustrations due to intermediate experience level. I found toolbox useless compared to distrobox. But using this with something like Arduino was annoying at best. The needed dependencies expected by whatever stuff I wanted to install was usually a big mystery with near useless error failure messages and names of packages and libraries totally unrelated to the package naming in DNF. When updating the base OS, stuff built in these containers is totally useless because I could not update the containers to the new OS image. Playing around with Flash Forth on a microcontroller was even worse. I ended up layering a bunch of stuff on the host because the containers were just not working. When I got an Nvidia machine, I went to Fedora Workstation and have had far fewer issues and frustrations. SB wasn't bad, but it is a pain to use these if you need kernel level access. Just my $0.02. I was actually on SB for ~2-3 years.