Basically, yes. Military theorists have been talking about this for a while. The lessons of Afghanistan and Iraq really demonstrated that it takes a remarkably small percentage of population being actively willing to fight against you in order to make it functionally impossible to pacify a region.
And the thing about Afghanistan and Iraq is that neither of them shared one of the world's longest land borders with the US. Trying to defeat an insurgency that can, whenever the fuck they want, strike at any part of your country, would be functionally impossible. That's really the one part of We Stand on Guard that Brian K Vaughan got wrong. The real insurgents would be riding their pickups down to Austin and blowing up hospitals and schools.