From my experience, if the guy you've known since High-school, who you've been the best man at his wedding - if that guy first ghosts you when you wanna hang out and then proceeds to say "Next weekend, I'm gonna make time, just for you." and then you text him up on Thursday to ask if he's still up to hang on the weekend, and he says "Woops, sorry something else came up." 4 WEEKENDS IN A ROW, then maybe, just maybe, you've reached a point where you lived yourselves apart.
Seriously, I know I'm not the most important thing in anyone's life, but I didn't want to find out first hand how unimportant I truly am. Ignorance is bliss.
PS: If that first sentence were any longer, it would reach the moon.