Speaking as a left-handed person it absolutely is a struggle, and given that the majority of the world is right-handed, for practical purposes it actually does need to be a struggle, otherwise ALL non-ambidextrous things would be a struggle for right-handed people instead, and that would be an even stupider way to run the world (as funny as it would be to see everybody else suddenly struggle with the things we struggle with on a daily basis, that's not a fair or sensible way to expect any civilization to function)

The things that left-handed people struggle with are due to subtle design issues caused by things that require asymmetric designs, you won't notice an obvious problem with the asymmetry as a right-handed person, but they're real struggles. Things like the shape being uncomfortable is only part of it, with scissors for example, the strength is coming from the wrong side, it won't cut properly, for things like writing, our hands smear the ink as we go or have to be held hovering above leading to strain and poor penmanship, spines and bindings immediately get in our way the moment we start trying to write, many things don't fit the way they're supposed to, don't have the correct angles when used in the left hand, or often they will block our vision or put our hand in a place that blocks our vision, whereas a right-handed person's hand does not block their vision using the same tool. The issues are complex and subtle, but they're significant, and they are not necessarily solved by simply making things symmetrical or reversing them. As much as lefties might enjoy a language that is written right-to-left, it's not a practical solution to the reality that we are a minority where things are designed for the majority.

Ironically the languages that DO write right-to-left, actually did not do it for the benefit of left-handed people, but did it to benefit right handed people, when they're chiseling into stone tablets as the hammer (in their left hand) would block their view. So if you want to know how it feels to be left-handed, go chisel some essays on a stone tablet. It'll make me feel better.