I'd like to offer the counterpoint that someone once advised me not to try weed until after I'd tried LSD, I followed that advice and I think it turned out for the better. There isn't exactly a benefit to being very impressed by the intensity of other drug experiences, and psychedelics can give you a sense of perspective about what you want out of life that's useful for navigating choices. They also tend to be self-deterring; you likely will feel more satisfied and grateful to have your feet on solid ground again after a trip, as opposed to immediately craving more, even if it was wonderful, which is a very convenient property many other drugs lack.

I've only done it a few times, but nitrous made me laugh so much, it was great. Nitrous starts fading as soon as you breathe out and is over in 10min tops, but for weed, give yourself an evening to get stoned for the first time. Feeling cramped for time is a huge vibe killer.

Also, modern weed can be way too strong for a first-timer, but if you can find a low-thc/high-cbd strain, you'll have smooth sailing. My poor in-laws hadn't smoked since the 60s, and the budtender sold them a thc vape, good times were not had. Don't make their mistake, haha.

Okay great. Now this stranger on the Internet would recommend not listening to that stranger on the Internet.

Do not take nitros oxide. Not only is it dumb as fuck, it literally gives you nerve damage, among many other side effects that anyone could find with a short simple search.

Weed and mushrooms are two of the best drugs on the planet and have minimal long term negative effects. I love mushrooms and it's all about dosage- how many grams and how strong is it per gram. NO it will not ruin your perception of other drugs. Acid is way stronger I'd recommend avoiding unless you have a whole week to recover.

Just vape weed or better yet take edibles and some mushrooms you should have near 0 negative physiological effects. Why tf would you do laughing gas you'll damage yourself what is this a street party in 2005 god damn. Not to mention just makes you act like a damn fool