Well, the Derossett case in 2019 confirmed that you can shoot plainclothes police who don't identify themselves if they're kidnapping someone from your home. Presumably that would extend to yourself too. Outside your property, I dunno. But as a bystander, there is tons of legal precedent that you can kill someone in the act of committing an armed robbery or some other forcible felony even if it's not directed at you, and that killing is not a crime. Murder, rape, and kidnapping also fall into this forcible felony category.

My best guess is a lower court would correctly conclude with a not guilty verdict, and it would keep getting appealed with a fast track to reaching the Supreme Court because ICE are a gang of losers. And then it depends on the can of worms that the Supreme Court is willing to open to appease their daddy.