Being able to assign a nameserver per interface with a domain wildcard is a fucking godsend. I use it every day with a hook script because my job uses some private domains but I don't want to send my entire DNS history through the VPN. Now ~job.com goes to tun0 and that's the end of it.

systemd-resolved is not perfect but with libnss's overly rigid nature the only alternative for my use-case would be to recreate similar functionality to resolved with dnsmasq – which is just objectively worse especially when you want to use DHCP sometimes but not always. Why reinvent the wheel? resolved does its job and does it well. I had some issues with it a few years ago but have been using it for the past couple years without complaint.