I agree with you that the Epstein case is relatively small compared to the millions of people who Trump is causing to suffer. However, the Epstein files also seem to be the first thing that cracked his base of political support. It is a weakness that anyone against Trump should exploit, not because it's the most important issue, but because it's the one that is most likely to remove him from power.
Deporting immigrants, locking up trans people, outlawing abortion, destroying free speech and political opposition, supporting genocide... These are all things that his base WANTS. They rejoice in the suffering of the "other". They care about the economy too, but they're told dumb to realize that Trump is the problem.