I don't know of an "out-of-the-box" distro for multimedia outside of Ubuntu Studio, but I do know of a utility that will turn any distro into a low-latency, pro audio setup: rtcqs - it runs 10-12 tests on your system and tells you how to set it up for realtime audio, if it isn't already - this is very much NOT what you asked for, but if you get your system going but it's not performing like you expect, this could be the thing that fixes all your issues.
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