Growing up in Texas, I knew none until after I came out. But, after I came out, one of my friends I had known pre transition also came out.
I believe I would have transitioned at least 5 years earlier if I had known any trans ppl. I just didn't know enough about the existence and effects of hrt, vaginoplasty, etc.
Even without knowing any lgbt ppl, I was thankfully still a leftist agnostic ally and not a homophobe.