It is, but most modern software doesn't work at all in Wine. I have 2 apps (Paint.net, and SketchUp Make 2017) which don't have any real alternatives (or they suck) for Linux and they don't work in Wine.

Sort of? In my experience, the people working on WINE have always been more interested in game compatibility. Sometimes other software will work, but it's a crapshoot.

Adobe shit doesn't work properly in wine

I can think of one: Excel Macros. If this had come out before May 2022, it would have saved me from needing to dual boot for a single assignment where I needed to do data analysis using Excel just two months after switching to Linux. It was literally around 2 hours of work, or less, and the entire dual boot setup took a similar time.

A lot of music production software doesn't rely on GPU acceleration. There's also proprietary bullshit like software that controls specific hardware, like GPU control software, MIDI devices and other random devices like things for RGB control or printers. Oh yeah, and tax software, to do taxes and whatnot, most of them are windows or mac exclusive, so that would come in handy too. I used to run a full-fat windows VM for things like these, but winboat might actually be a more tidy solution.

There's plenty of examples of software that either will never be created on linux or proprietary bullshit that devs simply can't be bothered to reverse engineer for linux.

Right, pretty much the bulk of my work use for my PC :( I guess I still need to wait a bit more before I can finally switch over...

PKhex, I hope. As long as it'll run it, PKhex needs not your GPU acceleration, it just gives me pokemon when I have nobody to trade with (or $999999999, change OT names, etc).

Although worst case scenario, it runs ok under wine, and for the trading I can actually use the Flipper 0, but not the OT names.

Can that not run through Proton? You could probably launch it through Steam, even if you bought your copy somewhere else. I have loads on external apps added just for easy setup with Proton