Back in the heady 1990s and 2000s, word on the street was that a drink or two a day, especially red wine, was good for health. “Everyone loved that story,” says Anya Topiwala, a psychiatric researcher at the University of Oxford.

Now the pendulum has swung. Drinking even a few times a week has been linked with numerous health problems, particularly cancer. Some public health agencies, the World Health Organization included, now say no amount of drinking is safe. Current U.S. guidelines suggest a maximum of two drinks a day for men and one drink a day for women.