Ortlieb bags seem pretty good in my experience. I have the backroller XL which is a pannier bag with a shoulder strap rather than a backpack. Plus they are made in Germany and not just a German company with outsourced production.
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The arkel brand has some super well made panniers.
https://arkel.ca/collections/bicycle-panniers/products/bug-pannier-backpack
North St bags makes a pannier backpack also.
They are both extremely heavy duty with high quality hardware, burly fabric etc
My favorite backpack brand is Osprey. They have a warranty that states, "we don't care if you bought it on 1972 (or something like that) or yesterday, we will fix it" which to me is awesome, better than a replacement. I've had great luck with their packs.
I recommend buying a brompton bicycle.

The rack being super low means the distance between the rear rack and the saddle is almost the exact height of a good backpack. IMHO, it's the best way to carry a backpack on a bicycle
Edit: Brompton's small front O-bag is actually made by Ortlieb. I wouldn't recommend their bags as backpack replacements. They work great on bicycles, but not so much on your back (where the weight should actually be on your hips)
I really liked this one where the backpack straps and panier attachments are on opposite sides of the bag, the conversion is quicker (just flip the top flap over) and it's more comfortable as a backpack than others I've tried. It got me through 4 years of college (overloaded with textbooks biking ~8 mi each way) but definitely started to show some wear, probably not quite as durable as an ortlieb but a great bag for $99.
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