I run Fedora at work that utilizes smart cards and socks proxies, several vpns and private certificates and it works like a charm.

I use Fedora for work. One piece of software I have won't run in wine though, because it does some weird SSL certificate stuff. So, I still need virtual machine manager. but, everything else, including compiling I updated our build tools to work properly in linux.

Fortunately, no smart cards or anything though, and unmanaged system

pacman -Rsn pacman

Laughs in # rm -rf /* --no-preserve-root