Anything by Alastair Reynolds is pretty big picture. Revenger is about space pirates with crazy unique lore. House of Suns spans tens of thousands of years and the whole galaxy. Terminal World is all on one planet but the concept is so unique it goes everwhere from a sci-fi wonderland to a western to airship pirates.

The Gods Themselves by Asimov stays pretty local to earth/the moon but there's whole other dimension, too.