Straight men are the least targeted group. If any of them feel targeted, it's because they are exactly the type of guy in the comic. I say this as a straight guy. Compared to my queer and women friends, I'm cruising through life. I might catch the occasional stray from a comic while they have to fear legislation limiting their rights.
My best friend of 15 years is the guy in this comic. I tried for years give him another perspective and keep him from going far right but it didn't work and now I've completely cut him off. I have no sympathy for somebody who is self victimizing. The actual victim is not the one that needs to change their behavior to protect the fragility of the wannabe victim.