Personally I like setting my campaigns, regardless of system, in some post-apocalypse. Preferably, I like to veil layers of how fucked the world is so the game gets more depressing the more the players dig.

In other words, I really like the current state of the metaplot! Gaia is fully dead, the Gehenna War is fully underway, the Fomorians have overthrown the Tuatha de Danán in Arcadia, the Acsension War has been lost and the Tempest has almost destroyed the Spell of Life, not to mention that Charon has been dead for ages and God is for all intents and purposes either dead or gone depending on your interpretation of the data.

In my game's canon, Lucifer tried to start the End of Days in 2005, but it didn't stick because of Banality undoing all his work. Now he's trying to figure out what Banality is and how to counteract it at scale, but for every step of progress he makes the world gets a little worse. Then COVID-19 happens, we all get stuck inside, the trods slam shut, and the Changelings have been slowly starving to death ever since. So, all hope of the End of Days happening is dead in the water for now.