Oh for sure, that's why it's late game! It's testing all of your skills that you picked up, and trust me after 5-6 factories I only now feel like I'm confident in knowing how to set it up. I remember I always wait for the alternate though that does not have sulfuric acid as waste, use the one that give sulfur as waste. Not having that liquid byproduct 100000% makes it better to work with, and then you aren't tinkering with delicate backfilling. "Hm, so 42% needs to come from backfill, vs the rest from production, so the valve needs to be at...".

Also it's much easier to do plutonium at the same time as uranium. I hold off on all nuclear until plutonium is fully unlocked. Now with ficsonium you could wait until that, but tbh plutonium waste I think is 1000x less than uranium, so you can wait on it.