I'm curious about trying Arch Linux, but I want to know what's difficult or impossible with it first, as that's usually what stops me sticking with a distro.

I'm particularly interested in software/driver support. For example, NVIDIA doesn't mention Arch in its CUDA download page.

UPDATE: OK it sounds like Arch is for bleeding edge. That sounds fun, but I like things simple and reliable, so I'll still with Ubuntu. I might run Arch on my secondary drive, or toy with it in Docker.