East coast super mutants don't have primary sex characteristics, West Coast ones do. The master was trying to explicitly trying to replace mankind with super mutants which required the ability to procreate, also you can hire a prostitute for Marcus in Fallout 2 and he jokes about it.

Tanya requires a computational orb to store and use magic effectively, presumably if you stripped her of said computational orb she would be rendered into a physically strong but overall standard human even if she can do magic manually itd probably be slow and severely reduced, just as I can hammer in a nail with a hammer but not with just my hand. Meanwhile even untrained force sensitives can still be human plus in nature due to innately enhanced reflexes and pretanatural instincts see kid Anakin and Han Solo for both. Also the upper limit for force sensitives is absurd see Valkorian/Vitiate/Tenebra for how busted they can get.