I'd be wary of supplements unless you're aware you're not getting enough of something in particular.
One of the best things I've found for combating fatigue is staying hydrated. Most people don't drink enough water, and dehydration makes fatigue worse.
Other techniques I can advise are anything that gives you some personal time to decompress a bit. Personally, I love doing things like reading or cooking to offset stressful activity that burns me out. I've also found regular exercise to help with fatigue: I do just a very basic combination of cardio and calisthenics 3 times a week.