IIRC, 98 needs a homebrew patch to not crash if you have more than 512MB of RAM.
Be careful, this DOS audio stuff is a rabbithole in and of itself. Apparently, no Sound Blaster emulation is perfect for all games and there are some things that only an ISA sound card can do. I think it was a fairly short list of problematic titles, though. I'll return to post a link if I can find it. Probably on the forums of vogons.org or vcfed.org