Tons of VST's work using yabridge.
Not Native Instruments though (their VST's should work but I can't get Native Access to run). And I don't run any VST's that need iLok.
Yabridge has a bug with wine versions later than (I think) 9.22, where the VST thinks the mouse is in another place than it really is.
Solutions are : make sure the VST window is at 0,0, or use an older version of wine, or there is a patch for yabridge that works in most cases, but hasn't been merged in yet. I'm running that.