Aiming for radio appeal and catering to the masses is ok, as long as you do it from the start.

Every musician/band I know of that changed their sound to be more radio friendly has given up their own sound.

The first example that comes to mind would be Kevin Parker; the first two Tame Impala albums are amazing, but since then he went full pop. It worked for a few songs, but recently his features in other songs were better than his own stuff (i.e. New Gold by Gorillaz and Neverender by Justice) IMO.

As far as AC/DC goes, I grew up with Black Ice, which is a decent album (albeit a bit bloated) but nothing I would necessarily would want to revisit any time soon. Pretty much all of their (popular) stuff sounds so big, yet lacks real depth in my opinion.