Depending on how all-in on the Apple you are, there will be a few main sticking points for you.
1: Gestures If you use a trackpad, you're going to have to adjust to a more limited set of gesture commands. The same with button mapping on a mouse. You'll almost certainly need to learn new ways to move around your desktops.
2: PDFs Preview is a godsend to Mac users. Preview does everything bar editing PDFs. You will no longer have Preview. You'll need to find three or four applications that replicate its features. And all of them will feel a bit lacking in comparison.
3: Apple Music Apple don't believe in Linux, so if you use AM and wish to continue listening to lossless on your computer, you're going to have to either use WinBoat to run a Windows VM into which you can install AM, or you're going to need to use Waydroid in order to run the Android version of the AM app. Neither is great, but both (mostly) work.
But ultimately it is worth it. I use my Mac much less than I used to, and my iPad almost not at all now.