I always turn subtitles on. I've played a handful of games with spatial audio, where NPCs are doing the walk and talk thing, sometimes being far enough away I can't hear. Subtitles make sure I don't miss the silly filler dialogue.
Also always invert the camera vertically. Early on, my brother explained how GoldenEye or Pilotwings or something, up looks down and down looks up. Now I'm married to that idea years later. Mainly in first person. I forget which way is natural in 3rd person, so I just invert for consistency there.