I don't think any car can ever have the acoustic qualities needed to tell the difference between FLAC 192/24 and a decent MP3. Assuming that's possible at all, but that's a different discussion.

I don't think I'd care to go through the trouble of replacing the headunit (which already supports Android Auto) to optimize for codec selection. If anything I'd replace the speakers.

But I don't use the car so much on local movement (german city, plenty of other options) and on the highway I think the noise is bit too loud to be worth it. I'll probably just wait until the current ones age enough to annoy me, then buy a nicer set.