Get yourself a vacuum sealer for foods you can repack and freeze (ie: meat), and get items you need smaller quantities of at a local grocery store. Costco's pharmacy has a very low filling fee, and the optical department has great prices. And, of course, you can get paper products.

I live in a 2 person household and use whichever is most sensible for what we need. In this economy, value for our money is important.