I am going through LE on Linux right now with my wife. I installed the ME3Tweaks Mod Manager using WINE and then installed mods through it designating my LE1, LE2, and LE3 directories in the Steam installation.

I have only installed the ME2 QoL mod of 1 probe getting all resources for a planet (after my wife experienced the tedium of probing planets for resources) so we could get back to playing. That mod has worked flawlessly so I would assume mods being installed through that Mod Manager are potentially just as stable.

Oh I didn't mod. She took off her mask. That's like, the sexiest thing! Good enough for me!

Its not the easiest process, but me le modding has been figured out. Here's a guide made for steam deck but the steps should apply to most distros. https://steamcommunity.com/sharedfiles/filedetails/?id=2924374014

I'm in the same boat, want FemShep, always romance Tali. The ME2 LE romance mod is pretty painless. Unfortunately, last I checked, the modder never finished the ME3 LE mod. There's a way to force it in ME3 by hacking the save file and it'll still get you there, but it won't be as seamless.