https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2014.00036/full
It's been in the works for over ten years. Here is a paper on research into it from 2014.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3000521/
Here's another one from 2010.
https://www.sciencedirect.com/science/article/pii/S1882761608000070#cesec60
And another from 2008.