A lot of mechanical keyboards these days are programmable using QMK Firmware. I actually use https://www.caniusevia.com/ instead though, which uses (a subset of) QMK under the hood but allows programming the keyboard via a Web app on the fly.

For my layout, I have the standard QWERTY layout for the unmodified layer (layer 0, holding no keys). Then I can hold down a thumb key for switching to a different layer, which has things like symbols, F1-F12, Home, End, etc. The layout I use isn't too far off the default Iris layout, just a few tweaks here and there (like one that allows me to hold a key for control, or tap that key for escape).