I'm writing this, sitting in a hotel room with the kids as my wife is outside chatting with her family.
Family or friends with can help quite a bit. Just someone there to take up some of the kids attention is really all you're asking for. If they want to do more than that, that's good too.
10 mo old is rough. I'd say, plan to be within 15-30 mins of a hotel for most of the trip. A lake/pool seems like a good option.