Injection works WAY better than pills and is easier on your liver. But there are sharp things and a reasonably high level of coordination required, so they want to try something else first.

It's weekly to fortnightly. I think whether pills are nicer or not is a matter of personal opinion, especially around needles. There's other factors too, pills have a very short half-life so your levels peak and trough over the course of a day instead of over a whole week or two. You can also generally get closer to average levels for cis women as well. Plus some side-effects like your liver working harder are eliminated.

Also, besides what some of the other comments said estradiol taken orally can increase blood clots/thromboses. It's really up to preference though. I started with patches, but switched to injections because despite some of the annoyances, the upside of only needing do an injection once a week instead of changing patches 2-4 times a week was very welcome, and needing to have a bunch of patches (and the residue they'd leave) on my skin was getting a bit annoying. But at the end of the day whatever works best for someone is the best method to use!