When you block that many groups how many new posts do you see? And how do you sort the posts?
I have only blocked a few groups but added a filter for posts containing trump or elon in the title as I get plenty of that crap from other sources.
Regarding the anime and furry posts, they come in waves so it's not constant or if I want to get a break from the yiffing I switch between sorting by Hot, Scaled and Top 6hrs.