So, it just froze on me about 10 minutes ago. I can drop to the console. The vm manager icon did not disappear from the menu bar, so I was wrong about that. Everything freezes. I cannot interact with any browser or any app. The mouse pointer did change from a pointer to hand over a link or something at one point, but never changed back. After dropping to the console, I eventually just had to reboot and restart everything. The best way to describe it is, someone replaced my desktop with an image, and the only thing that still works is moving the mouse around.
I'm thinking it's been about a week or so since it did this last. Oh, and I was poking around on a web page when it did it. Web browsers are always involved, but not specifically any one browser.