they calm down when no one's pissing them off

I thought the main issue with ones that went nuts is that they were mass murderering cannibals.

totally different, it's actually bloodborne. but it came out first. the Manga is significantly better, the anime rushed a lot of stuff and skipped a lot of plot entirely particularly overthrowing the organization. it is an island ran by weird scientists who are creating mutant humans as weapons to fight a war somewhere else, but that's just the backstory, the real gem is that it's a deconstruction of 'even more power' fight centric manga where the hot girls are actuality well written characters who may have malnutrition and look hot in babe armor, but they're covered in horrifying scars and horrible to see naked. and after they quickly realize they're all being duped the women overthrow the scientists then try and kill off all their living failed experiments who are some men but mostly other women who went nuts from unresolved trauma and cosmic horror blood, so they keep fighting and leveling up and even more power than before-ing, and the whole time a cute twink that's been claimed by our main character, hangs out with the bad guys long enough to realize they're all just people with massive trauma fighting other people with massive trauma and they all need therapy and at the final fight he cries and stops them from fighting and tells them they're all valid in their own way and they realize they don't need to kill each other, after watching the cute twink cry and whine. it's fantastic. highly recommend.

It's a fine line between superweapon and supervillian.

I only watched the anime, but it is basically Attack on Titan.

just remember they're all one irritation away from transforming into an unstoppable monster that will cut off all your limbs.