OP, I'll be honest with ya: if you're looking for something akin to M$ Defender but on Desktop Linux (and free), you ain't gonna find it.
A quick look at your Lemmy history suggests that you're security-conscious. In that context, it's worth noting that 'Linux' does provide you. However, depending on your situation and/or threat model, this might come at the cost of expertise.
If you never download random stuff from the internet, then your average distro might be sufficient as long as you commit to the most basic set of best practices.
However, if you do download random stuff from the internet OR if your situation and/or threat model warrants a more conscious approach, then things might change substantially.
But before subjecting you to Qubes OS, we'd have to know more about your situation. So, first of all, could you elaborate on your use case of ClamAV? Or, perhaps even what you intend to do in general?