Having used it in the browser, it barely works in a browser. >50% of functionality is simply missing. Pretty much only the very very basics of typing and formatting.

I also use libreoffice and actually like calc better than excel because python support ia a first class citizen for programming within the spreadsheet in Calc, but AFAIK macro spreadsheets aren't very cross compatible, but I guess I work in engineering so every company I have worked with or for uses excel macros, probably not representative of other professions.