Yes, Trisquel can be a pain to be used as a daily driver. Whilst I admire the philosophy behind it's concept, it definitely leaves a lot of end work to be done by the user.
I have used Fedora for quite some time in the past . I think Fedora and now discontinued Cent OS were two RPM based distros (I think Fedora now uses Dnf as well) I have used. Cent OS I liked decently, it wasn't as bleeding edge as Fedora and for a long time I dual booted Cent OS and Debian.
Void is decent independent distro. Ironically I don't have any anti systemd feelings and just gave it a try for heck of it and stuck to it. I think there is a musl version of Void as well but that makes things only complicated.