So, I regularly run Shadowrun as a "My first RPG" and as a "Wait, D&D isn't the only game?", but I do it by replacing the mechanics entirely.
If you want something official, Shadowrun Anarchy is actually pretty good. Otherwise, look at The Sprawl, or Runners in The Dark (A Blades in the Dark hack). And I guess at some point I'll get around to actually releasing the custom system I'm using to run it for my current games.