In the End of Evangelion movie, Misato kisses Shinji and says "We'll do the rest when you get back." I don't know if I would count this as grooming though, because Misato was literally dying this was likely intended purely as motivation to appeal to a dumb 16 year old boy's brain. I mean, the next shot is Misato laying on the ground dying in a pool of her own blood. Up to that point Shinji was refusing to pilot Unit 01, and Misato was begging him to pilot it (again lol) in that scene, and unfortunately even a dangling carrot of sex wasn't enough to motivate him to save humanity.

Some say there is another part in epidose 23 where Misato also attempts to have sex with him, but I don't remember it well. Describing the relationship between Shinji and Misato is a difficult one, because Misato fills many roles throughout the show. So too it is hard to really say if Misato is actually a groomer or not, because of the context of what happens in the show/End of Evangelion film. She doesn't have the exact same role in the Rebuild movies. The meme is probably because everyone remembers her kissing Shinji in End of Evaangelion, but they probably all forgot she literally died in the same scene.

These characters are definitely fictional, I can tell from the speech bubbles and flat textures.

Especially Misato.